Synthesis and Spectral Characterization of (E)-2-Amino- N'-[1-(2, 4-dihydroxy phenyl) Ethylidene] Benzohydrazide: Its Cytotoxicity

Anthraniloyl hydrazones contains one free -NH2 group attached to the aromatic ring and the other is the hydrazinic –Nitrogen. The H-NMR and D2O exchange studies inferred that the amide N-C=O and phenolic –OH are involved in hydrogen bonding. The mass spectrum of the ligand shows dimer peak. The anthranil hydrazides possesses antioxidant activity and also some of the hydrazone ligands are used in the treatment of iron overload diseases. As these Schiff base ligands are known for their wide range of applications in pharmaceutical and industrial fields for their antitumor properties the cytotoxicity of the ligand is studied. The ligand ADHPEBH is characterized by different analytical methods like mass, ir, H-nmr and D2O exchange. This paper provides an overview of the synthesis, analytical characterization, types of hydrogen bonding and cytotoxicity of the title compound.